Description
3D Molecular Designs. Model how the Cas9 protein is programmed with RNA to search for and identify specific sequences of DNA before making the double-stranded cut. Explore and discuss how Cas9 is being engineered with new features that make it a useful tool for editing the human genome. Students can use the colorful foam pieces and placemat in this set to:
- Build a schematic model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA
- Understand how the Cas9 protein binds to a specific sequence of viral double-stranded DNA at a PAM site—and cuts it
- Demonstrate how that cut destroys viral genome and prevents the infection of bacteria
- And more
Set equips 1 group of 4 students. Go to the 3D Molecular Designs website for additional resources: PDFs of Teacher Notes (an activity guide) to help you consider different ways to use the materials and additional resources to supplement or reinforce concepts presented in the classroom.